报告题目1：Studying human respiratory syncytial virus infection using proteomics from patients to cells

　　报告人：Prof. Julian Hiscox （University of Liverpool）

　　报告时间：2018年3月4日　上午9:30-11:00

　　报告地点：动物医学院 二楼会议室（4245）

　　摘要：Human respiratory syncytial virus (HRSV) is a major human pathogen infecting children worldwide. The virus is particularly harmful in the immunocompromised and the elderly. The virus targets respiratory epithelial cells and there are currently no licensed vaccines and anti-viral therapy is infective unless patients are treated early enough in infection. The work has focused on using quantitative proteomics to understand the interaction of HRSV in both patients and cell culture models, including three dimensional air-liquid interface cultures, which differentiate and model the human airway. Further, they have used quantitative proteomics to define viral/host protein-protein interactions and identify new therapeutics targets.

　　报告题目2：Understanding Ebola virus disease in humans

　　报告人：Prof. Julian Hiscox （University of Liverpool）

　　报告时间：2018年3月5日　下午15:00-16:30

　　报告地点：动物医学院 二楼会议室（4245）

　　摘要：Ebola virus (EBOV) is a high consequence infection and a Biosafety Level 4 pathogen.  Case fatality rates with the virus are on average 60% to 70% of people who become infected.  The virus causes Ebola virus disease (EVD). The lethality and devastation this virus causes was recently illustrated in the West African outbreak between 2013 and 2016. Prof. Julian laboratory deployed to Guinea in West Africa to help with molecular diagnosis and research. They used high resolution sequencing to map virus evolution and determine the host response. The data showed distinct differences in acutely ill patients who went on to survive EBOV versus those that died.  Further, they showed the presence of bacteria and parasites in the blood of EBOV infected patients and this data has implications for care management protocols.

　　报告人简介：

　　Prof. Julian A. Hiscox is Chair in Infection and Global Health, in the Institute of Infection and Global Health (IGH) at the University of Liverpool.  His laboratory focuses on respiratory and emerging diseases and uses high resolution approaches such as RNA sequencing and proteomics to understand how viruses interact with the host.  His laboratory has been working on Ebola virus since 2012 studying the evolution of the virus and interaction of viral proteins with host cell proteins.  During the 2013-2016 Ebola virus outbreaks his laboratory leads the sequencing efforts for the European Mobile Laboratory.  The work of his group has been published in the journal Nature and other high impact publications.  His seminar will focus on studying this very dangerous virus in humans and what we learnt about Ebola virus disease during the outbreak.

动物医学院

2018年2月28日

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