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报告题目:定量合成生物学 (2021年生命科学研究进展系列讲座之二十)

报告人:刘陈立

报告时间:2021年12月9日(星期四)16:30

报告地点:北校区八号教学楼N8T07

报告摘要:

       合成生物学(又称工程生物学)采用工程化的设计理念,通过对生物体进行设计、改造和合成,创建人工生命体系。定量生物学应用严谨的数理逻辑思维研究生物系统基本原理,旨在用简单定量关系描述复杂生物过程。合成生物学自下而上的工程化思维,使人们能够通过构建合成生物系统,验证定量生物学对生命现象的定量预测;反过来,定量生物学发展的定量基础理论又能够帮助人们理性设计合成生命体,应对人类社会面临的重大挑战。定量生物学和工程生物学的交叉互补将大大促进生物学科发展。然而,国际上真正将这两个学科领域紧密联系起来的研究还很少。本研究围绕单细胞和多细胞层面,揭示天然和合成生物系统都符合的普适性定量规律,应用于合成生物系统的理性设计和定量预测。

报告人简介:

       刘陈立研究员,博士生导师,国家杰出青年基金获得者,现任中国科学院定量工程生物学重点实验室主任,中科院深圳先进技术研究院合成生物学研究所所长,深圳合成生物学创新研究院院长,深圳合成生物研究重大科技基础设施首席科学家,《合成生物学》杂志执行主编,《Engineering Biology》《mLife》杂志副编辑,《ACS Synthetic Biology》《Quantitative Biology》《生命科学》等杂志编委,国家重点研发计划首席科学家,享受国务院特殊津贴专家。香港大学博士,美国哈佛大学博士后。荣获“中国科学院青年科学家奖”“中国科学院优秀导师奖”“中源协和生命医学奖创新突破奖”等奖项。实验室致力于定量合成生物学研究,基于“定量解析、合成重构”的研究思路,聚焦复杂生物系统形成过程的基本原理,合成生物系统的理性设计原理等重要科学问题开展工作。特别是探索细菌生长定植的数学规律,以及基于此开发抗肿瘤细菌新疗法。

      《生命科学研究进展》是西北农林科技大学博士一年级课程。该课程将邀请生命科学不同领域的优秀教授讲授各领域的最新研究进展和他们自己的科研工作。

       欢迎广大师生参加!

生命科学学院

2021年12月6日


附:英文网通知

Notice of “Quantitative Engineering Biology: Build-to-learn-to-build”


Title: Quantitative Engineering Biology: Build-to-learn-to-build

Time: 4:30 pm, December 9, 2021

Venue: N8T07


Abstract: The bottom-up engineering approach of synthetic biology enables the construction of synthetic biological systems to test the quantitative predictions of life phenomena by quantitative biology, leading to new understanding; In turn, development of the basic theory of quantitative biology can help the rational design of synthetic living organisms, addressing major challenges facing human society. The cross-fertilization of quantitative biology and synthetic biology will greatly promote the development of the biological sciences. However, there are few studies in the world that connect these two subject areas closely. This talk encompasses research at the single- and multi-cell levels, to reveal the universal quantitative laws consistent with both natural and synthetic biological systems, and apply them to rational design and quantitative prediction of synthetic biological systems.

Introduction of Speaker:

Bio: Chenli Liu is a Professor in Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, the Director of CAS Key Laboratory for Quantitative Engineering Biology, the Director of Shenzhen Institute of Synthetic Biology (iSynBio), the Chief Scientist of Shenzhen Synthetic Biology Core Facility, the Deputy Director of Synthetic Biology Specialized Committee in Chinese Society of Bioengineering, and the Chairman of Shenzhen Synthetic Biology Association. He also serves as an Editorial Advisory Board member of journals ACS Synthetic Biology and Quantitative Biology. Liu obtained a Ph.D. in Biochemistry from the University of Hong Kong, and postdoctoral training in MCB, Harvard University. The research interest in his lab currently focuses on bacterial cancer therapy, bacterial cell cycle, and directed evolution.